New study: Chinese folk medicine displays remarkable anti-arthritis activity

Diu Le Bang, a folk medicine derived from the roots of the nappy tree (Claoxylon indicum Hassk.), has long been used in traditional Chinese medicine to treat symptoms of rheumatoid arthritis. In a study in BMC Complementary and Alternative Medicine, researchers found that Diu Le Bang possessed significant anti-arthritis activity based on models with adjuvant-induced arthritis (AIA) mice.

• Diu Le Bang is known to relieve swelling of the foot, including lumbocrural pain and foot edema.
• In the study, researchers tested whether the ethanol extract from Claoxylon indicum (CIE) could be used to improve adjuvant-induced joint arthritis.
• Researchers evaluated the severity of arthritis in mice using arthritic scores, hind paws edema and spleen index, and histological examinations. Biomarkers, such as interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α), were collected in the knee joints for further tests.
• The findings revealed that mice treated with CIE had significantly lower inflammatory responses based on results from paw swelling, hyperplasia of lymphatic tissues, and synovial membrane.
• CIE also decreased biomarkers for inflammation such as IL-1β and TNF-α expression in arthritic joints.

The authors concluded that CIE could be used to inhibit arthritis activity and potentially treat rheumatoid arthritis.

Read the full study at this link.

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Journal Reference:

Chen Y, Wang Q-W, Zuo J, Chen J-W, Li X. ANTI-ARTHRITIC ACTIVITY OF ETHANOL EXTRACT OF CLAOXYLON INDICUM ON FREUND’S COMPLETE ADJUVANT-INDUCED ARTHRITIS IN MICE. BMC Complementary and Alternative Medicine. 5 January 2017;17(11). DOI: 10.1186/s12906-016-1500-7