antibiotic resistance

After fracturing her leg, a 70-year-old woman from Nevada was hospitalized. After surgery, she developed an infection in her hip. Medical professionals tried to control the infection with several antibiotics, but all of them failed. The woman was facing a superbug that had evolved at the DNA level.

The 26 antibiotics available in the US, including last-line antibiotic colistin, were unable to stop the infection. The result was tragic; the woman’s microbiome was overtaken by the highly evolved superbug and the infection killed her. During the struggle to survive, the woman was isolated so the bacteria would not spread to other weakened patients in the hospital. According to microbial tests taken from other patients, the drug-resistant superbug did not spread; however, a superbug’s ability to spread is only half the problem. The other, more troubling problem with super bugs is their ability to lurk quietly inside the human gut until they find an opportunity to take advantage of a microbiome newly weakened by a round of antibiotics.

The real threat of superbug infection occurs due to a bacteria’s ability to evolve when antibiotics are administered

Patients are often admitted to the hospital with compromised microbiomes and weakened immune systems. The addition of more antibiotics allows these lurking, resistant superbugs to take control of the patient. As increasing use of antibiotics depletes the good microbes in the individual’s gut, superbugs are able to destroy the balance and take over the patient’s immune system. When there are not enough protective microbes in the gut, the superbug can take command and an infection manifests. The real threat of super bugs is their ability to manifest when a patient is given antibiotics. (RELATED: Read more about the failures of chemical medicine at Medicine.news)

Colistin is an antibiotic that is reserved for resistant super bugs, yet resistance to this drug has emerged as of recent. The scientists are finding out that resistance to colistin is caused by a single evolving gene called mcr-1. This gene is special because it can transfer between bacteria rather easily via free floating DNA called plasmids.

Plasmids are swapped in the gut of humans, as bacteria interact. If the individual obtains a bacterium with a plasmid that carries resistance to colistin, the bacteria may lurk in the gut and be held in check; however, the bacterium becomes infectious when antibiotics are administered. The antibiotics kill everything except for the resistant bacteria. This failure of modern medicine allows the newly-equipped super bug to fill the void and manifest infection in the body. With no microbial competition to hold the infectious bacterium accountable, the super bug takes control. (RELATED: Follow more news about Big Pharma at BigPharmaNews.com)

Antibiotic resistance occurring rapidly, across multiple bacteria species

Scientists warn that a single bacterium might collect multiple plasmids with multiple genes for resistance to multiple antibiotics. These infections can occur for multiple types of bacteria; tests have shown that E. coli has developed resistance through this same mcr-1 gene. One of the most recent super bugs to manifest came from the overuse of an antibiotic class called carbapenems. In 2009, scientists quickly found that the super bug had developed resistance through the gene, ndm-1, which allowed the bacteria to survive against the antibiotics that were once so heavily relied upon to treat it.

The real threat here is not the spread of a super bug from one person to the next. The real problem is the weakening of microbiomes via antibiotics which allows isolated cases of super bug infection to manifest, time and time again, in new places. Even if a hospital can control a super bug in the moment through isolation and sterilization, the real threat could manifest again and again, somewhere else.

Sources:

CDC.gov

Not all honey is created equal. While the benefits of raw, unprocessed honey have been well-documented over the centuries, Australian researchers have found one type of honey, called Manuka honey, to be better than all known antibiotics.

Manuka honey is produced by bees that forage on the nectar of Leptospermum Scoparium, or New Zealand’s Manuka bush, as well as tea trees, native to Australia and New Zealand only.

This remarkable type of honey not only effectively kills bacteria, but none of the bugs killed by it have been able to build up immunity. In a world where many of the last resort antibiotics are failing against antibiotic-resistant superbugs, Manuka honey may hold the key to fighting resistance issues, saving thousands of lives worldwide.

Manuka honey fights superbugs

Dr. Dee Carter from the University of Sydney’s School of Molecular and Microbial Biosciences noted that antibiotics not only have short shelf lives, but the bacteria they attack quickly become resistant as well, making them useless over time.

The report, published in the European Journal of Clinical Microbiology and Infectious Diseases, claimed that Manuka honey killed almost every bacteria and pathogen it was tested on. Unlike all antibiotics available on today’s market, none of the bugs tested were able to survive the honey treatment.

According to Dr. Carter, there are particular compounds, like methylglyoxal, in the Manuka honey that cause multi-system failure in the bacteria, killing them before they are able to adapt and build up immunity.

What Manuka honey can do for you

Manuka’s biological properties range from antioxidant, anti-inflammatory, antibacterial, antiviral, antibiotic and wound healing, to immune-stimulatory. However, what separates Manuka honey from the rest is that its antibacterial powers challenge even the toughest superbugs, such as the life-threatening methicillin-resistant Staphylococcus aureus (MRSA).

Manuka honey is marketed for cancer treatment and prevention, high cholesterol, chronic inflammation, diabetes, the treatment of gastrointestinal problems, and eye, ear and sinus infections. However, it might be most useful in treating skin wounds and leg ulcers.

According to one study, published in the scientific journal Peer J, chronic wounds are becoming a major global health problem, due to antibiotic resistance issues. They are costly and difficult to treat, and bacterial biofilms are important contributors to the delay in healing. There is an urgent need for new, effective agents in topical wound care, and honey has shown some great potential in this regard.

For their study, researchers reviewed Manuka honey in particular as an alternative treatment for wounds because of its broad-spectrum antibacterial activity and the inability of bacteria to develop resistance to it. Their study indicated that honey might prevent bacterial biofilms and eliminate established biofilms. Furthermore, they reported that Manuka honey could successfully be used to kill all MSSA and MRSA biofilms in a chronic wound, supporting the use of this type of honey as an effective topical treatment for chronic wound infections.

In recent years, word of the biological benefits of Manuka honey has spread to every corner of the world, turning it into one of the most popular superfoods out there. Its fame and the over-demand, however, have caused shortages, resulting in fake, usually cheaper, products to enter the market. So, if you are going to spend your money on honey to reap its benefits, make sure you are buying the real thing.

Sources:

TrueActivist.com

EssentialHealthAdvisor.com

NCBI.NLM.NIH.gov

Link.Springer.com

Emerging superbug kills woman: Infection resistant to 26 antibiotics

The real threat of superbug infection occurs due to a bacteria’s ability to evolve when antibiotics are administered

Antibiotic resistance occurring rapidly, across multiple bacteria species

Study: Manuka honey kills more bacteria than all available antibiotics

Manuka honey fights superbugs

What Manuka honey can do for you