Lantana grisebachii found to prevent bioaccumulation of arsenic in rat splenocytes

In a study, researchers found that Lantana grisebachii, a plant native to South America, can counteract arsenic toxicity in vivo. Their findings were published in the Journal of Dietary Supplements.

• Arsenic is widely considered an immunotoxic agent; it is present in contaminated waters and consumed by humans.
• Phytotherapy can potentially counteract the adverse effects of arsenic consumption.
• The researchers proposed that L. grisebachii can protect against arsenic toxicity, given its in vitro bioactivity.
• For the study, the team looked at whether aqueous L. grisebachii extract can protect against arsenic toxicity in rat splenocytes.
• The researchers obtained splenocytes from an arsenicosis rodent model that was first treated with either a placebo or L. grisebachii extract for 30 days.
• They then analyzed arsenic content (total reflection X-ray fluorescence), fatty acid profile (gas chromatography), y-glutamyl transpeptidase activity (Szasz method), peroxides (xylenol orange-based assay) and nitrites (Griess reaction) in viable splenocytes.
• Data was analyzed with ANOVA and the Tukey’s test.
• The findings revealed that L. grisebachii extract was able to prevent damage to splenocytes by preventing the accumulation of arsenic in cells and stopping arsenic from inducing lipid peroxidation.

In sum, aqueous L. grisebachii extract was able to counteract arsenic toxicity in rats.

Learn more about plants that can counteract heavy metal toxicity at HeavyMetals.news.

Journal Reference:

Ramos Elizagaray SI, Quiroga PL, Perez R, Sosa C, Perez A, et al. EFFECT OF THE AQUEOUS EXTRACT OF LANTANA GRISEBACHII STUCK AGAINST BIOACCUMULATED ARSENIC-INDUCED OXIDATIVE AND LIPID DYSFUNCTION IN RAT SPLENOCYTES. Journal of Dietary Supplements. 29 June 2018; 16(4): 401-407. DOI: 10.1080/19390211.2018.1470124